Dezfulian C, et al. - A single-center, pilot trial of low dose sodium nitrite (1 or 9.6 mg dose) vs. placebo in hospitalized out-of-hospital cardiac arrest (OHCA) patient was planned to assess whether nitrite administration reduced blood pressure and whether whole blood nitrite levels increased in response to nitrite administration. Findings revealed no significant hemodynamic effect of low dose sodium nitrite in patients with OHCA, which suggests that nitrite can be delivered safely in this critically ill patient population. Researchers observed the necessity for higher doses of sodium nitrite for achieving target serum level of 10 μM.