Kantri A, Ziati J, Khalis M, et al. - To better identify cases affected by the coronavirus disease (COVID-19) at an early stage and stop disease progression to an advanced stage, several studies have been performed to determine the clinical, biological, and radiological characteristics of COVID-19. With the aim to enrich the literature, researchers here critically analyzed the clinical and biological characteristics of 134 patients from the North African Mediterranean region, including numerous genetic, epigenetic, and environmental factors that may affect disease evolution. Risk factors for progression to severe disease were: advanced age, presence of comorbidities, male gender, and infection in ethnic or family groups. Progression to severe disease was observed in strong correlation with the presence of abnormalities in the following parameters: white blood cells (WBC), neutrophils, lymphocytes, C-reactive protein (CRP), procalcitonin, D-dimers, lactate dehydrogenase (LDH), ferritin, creatinine, aspartate aminotransferase (ASAT), and alanine aminotransferase (ALAT) during both admission and hospitalization. On the basis of these results and an extensive literature review, clinicians are recommended to closely monitor the biological parameters recognized herein and perform immunological and genetic studies.