Ximenes R, et al. - A systematic review (SR) of SRs after Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was carried out in order to integrate the literature on health outcomes related to Zika virus (ZIKV) infection in humans. The search generated 1,382 unique articles, of which 21 SRs met the inclusion criteria. The 21 SRs varied from descriptive to quantitative data synthesis, including four meta-analyses. Microcephaly, congenital abnormalities, brain abnormalities, neonatal death, and Guillain-Barré syndrome were the most ordinarily reported ZIKV-associated manifestations and health outcomes. The involved reviews were greatly heterogeneous. With all studies having more than one critical weakness, the overall quality of the SRs was extremely low. Thus, the evolving character of the literature on ZIKV-associated health outcomes, collectively with the extremely low quality of existing SRs, shows the demand for high-quality SRs to escort patient care and notify policy decision making.