Suzuki S, Kaikita K, Yamamoto E, et al. - In view of recent work proposing the H₂FPEF score (0–9 points) as valuable for the discrimination of HF with preserved ejection fraction from non-cardiac causes of dyspnoea, researchers examined the predictive value of the H₂FPEF score for future HF-related events in stable outpatients with cardiovascular risk factor(s) in Japan in this external validation study. The H₂FPEF score includes following six clinical and echocardiographic variables: (i) obesity (H); (ii) the use of ≥ 2 antihypertensive drugs (H); (iii) atrial fibrillation (F); (iv) pulmonary hypertension (P); (v) an age > 60 years (E); and (vi) E/e' > 9 (F). In this prospective cohort study, they included 356 outpatients (171 men, 185 women, mean age 73.2 years) with mean H₂FPEF score of 3.1 ± 1.8. HF-related events developed during the follow-up period in 15 patients; these included cardiovascular death (n = 2) and hospitalization for HF decompensation (n = 13). As per multivariate Cox proportional hazards analysis, the H₂FPEF score is an independent predictor of future HF-related events. These findings support the value of H₂FPEF score for assessing valuable information for future HF-related events in stable outpatients with cardiovascular risk factor(s) in Japan.