Tanzilli G, Truscelli G, Arrivi A, et al. - Fifty consecutive individuals with ST-elevation myocardial infarction who were scheduled to undergo primary angioplasty were recruited in this study to see if the infusion of glutathione (GSH) prior to acute reoxygenation could counteract the harmful influences of higher H₂O₂ generation on myocardium. In comparison with placebo, a significant decrease of H₂O₂ production and 8-iso-PGF2α levels and a significant rise in H₂O₂ breakdown activity and nitric oxide bioavailability was discovered in the GSH group after acute reperfusion. Reduced production of H₂O₂ continued up to 5 days after the index procedure in treated individuals, and these variations were connected to those of the cardiactroponin T levels. The infusion of GSH appeared to trigger a rapid onset and persistent blunting of H₂O₂ generation enhancing myocardial cell survival.