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Global review of the age distribution of rotavirus disease in children aged <5 years before the introduction of rotavirus vaccination

Clinical Infectious Diseases Jan 31, 2019

Hasso-Agopsowicz M, et al. - Researchers looked for datasets with granular age distributions of rotavirus-positive presentations among children <5 years of age before the introduction of rotavirus vaccines. Researchers identified 117 datasets. Countries with very low/low child mortality had rotavirus-positive hospital admissions at a median age of 65 weeks whereas countries with very high child mortality had hospital admissions at a median age of 38 weeks. They observed 69% of rotavirus-positive admissions <5 years were in the first year of life in countries with very high child mortality, and 3% were by 10 weeks, 8% were by 15 weeks and 27% were by 26 weeks. This information may assist in determining the potential benefits of different rotavirus vaccination schedules in different countries and for monitoring program impact.

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