Wong MCS, Huang J, Huang JLW, et al. - Through a systematic review and meta-analysis of population-based, observational studies (n = 70) that reported the prevalence of colorectal neoplasia, comprising 637,414 individuals, researchers investigated the prevalence of any type of adenomas, advanced adenomas (AADs), and colorectal cancers (CRC) according to age, gender, ethnicity, geographic regions, and anatomic location (proximal vs distal). Following the calculation of the overall prevalence rates of adenoma, AAD, and CRC, subgroup analysis intimated that among men vs women, among older adults vs younger adults, among Caucasians vs other ethnicities, in European countries vs other countries, and among patients with proximal vs distal neoplasia, prevalence values of adenomas, AADs, and CRCs were higher. A high prevalence of colorectal neoplasia among some populations was noticed in this meta-analysis, which intimated a requirement to extend CRC screening programs for these groups. Moreover, the pooled prevalence estimates could be utilized as quality indicators for traditional CRC screening programs.