Jabbari Shiadeh SM, et al. - Researchers examined Enterococci blood isolates from hospitalized patients in different regions of the world regarding the frequency and time trend of their antibiotic resistance. Searching literature from January 1, 2000, to May 20, 2018, using Medline (via PubMed), Embase, and Cochrane Library and all original publications, they included a total of 291 studies in the meta-analysis. Findings revealed a significantly high prevalence of vancomycin-resistant E. faecium in bloodstream infections; this was particularly observed in Eastern Mediterranean countries. This represents a massive warning signal for resistance to this broad-spectrum antibiotic. Between all antibiotics, based on the WHO original offices, American countries recorded the lowest prevalence of resistance for linezolid in Enterococcus faecalis. Findings highlight the essentiality of establishing appropriate antibiotic usage guidelines in these countries.