Global incidence trends in primary liver cancer by age at diagnosis, gender, region, and etiology, 1990‐2017
Cancer Apr 07, 2020
Liu Z, Suo C, Mao X, et al. - By utilizing data on primary liver cancer (PLC) between 1990 and 2017 from Global Burden of Disease Study 2017, researchers determined the incidence trends as well as the patterns of PLC related to different age at diagnosis. Worldwide, a reduction in the number of PLC cases for which the age at diagnosis was < 30 years was reported, from 17,381 in 1990 to 14,661 in 2017, whereas a rise was evident in the number of PLC cases diagnosed at age 30 to 59 and ≥ 60 years old, which was from 216,561 and 241,189 in 1990 to 359,770 and 578,344 in 2017, respectively. In both genders, a reduction was noted in the age‐standardized incidence rate (ASR) of PLC cases with age at diagnosis < 30 years and between 30 and 59 years, whereas the ASR of PLC with age at diagnosis ≥ 60 years was identified to be increased in men and continued to be stable in women at the global level. Findings revealed that the potent control of hepatitis, particularly in young and middle‐aged individuals, was responsible, partly, for causing alleviation of PLC in highly endemic areas. However, the most developed countries and elderly populations demonstrated an unfavorable trend. As such, paying more attention on nonalcoholic steatohepatitis and elderly patients was recommended for PLC prevention schedules.
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