Fournier S, Collet C, Xaplanteris P, et al. - The present study was sought to evaluate the value of global fractional flow reserve (FFR) in predicting long‐term clinical outcomes of patients with stable coronary artery disease but no ischemia‐inducing stenosis. Researchers examined major adverse cardiovascular events (MACEs: all‐cause death, myocardial infarction, and any revascularization) after 5 years in 1,122 individuals without significant stenosis (all FFR >0.80; n=275) or with at least 1 significant stenosis successfully treated by the percutaneous coronary intervention (ie, post–percutaneous coronary intervention FFR > 0.80; n=847). This study’s findings revealed that even in the absence of ischemia‐producing stenoses, patients with a low global FFR, the physiologic correlate of global atherosclerotic burden, present a higher risk of themajor adverse cardiac event at 5‐year follow‐up.