Ward ZJ, et al. - A microsimulation model was developed as well as calibrated in this study to estimate childhood cancer survival for 200 countries and territories worldwide, accounting for various factors that influence cancer outcomes in children. Using the aforementioned model, the estimated global 5-year net childhood cancer survival currently is 37.4%. Superadditive gains were obtained with the adoption of a comprehensive systems approach including all policy interventions, with a global 5-year net survival of 53.6% at 50% scale-up and 80.8% at full implementation. Wide regional variations were reported for childhood cancer survival, which is especially poor in Africa. Although it is important to focus on the expansion of access to treatment (chemotherapy, radiation, and surgery) and financial toxicity, the attainment of improved childhood cancer outcomes across the globe require investments that improve the quality of care at both the health-system and facility level.