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Genome-wide association study of coronary artery disease among individuals with diabetes: The UK Biobank

Diabetologia - Clinical and Experimental Diabetes and Metabolism Sep 07, 2018

Fall T, et al. - In 15,666 unrelated people (3,968 CAD cases and 11,698 controls) of white British ancestry with diabetes at inclusion in the UK Biobank study, researchers carried out a genome-wide association study of coronary artery disease (CAD) to identify genetic variation correlated with CAD among individuals with diabetes. In participants with and without diabetes, large similarities were found with the genetic architecture of CAD. There was genome-wide significant evidence for association with CAD at the previously well-established LPA locus and at 9p21. Evidence that the genetic architecture of CAD is largely the same was indicated by other variants previously associated with CAD showing similar effects in the participants with and without diabetes.

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