Perrot N, et al. - In this investigation, researchers analyzed the correlations of LPA variants with calcific aortic valve stenosis (CAVS) in a cohort of patients undergoing heart surgery and LPA with CAVS in patients with coronary artery disease (CAD) compared to those without CAD and determined if first-degree relatives of patients with CAVS and high levels of lipoprotein(a) (Lp[a]) showed evidence of microcalcification of the aortic valve. Participants in the study were 1,009 people undergoing cardiac surgery and 1,017 control candidates in the QUEBEC-CAVS cohort. The data presented in this work showed that, independently to presence of CAD, a genetically elevated level of Lp(a) was linked to CAVS. While the outcome of Lp(a)-lowering therapy in patients with mild-moderate CAVS or patients at high risk of developing CAVS still needs to be established, these outcomes provide evidence that routine evaluation of Lp(a) levels in CAVS patients as well as first-degree relatives may be clinically useful.