Pomares C, et al. - Given that in Europe most of Toxoplasma gondii genotypes belong to the type II lineage, in Latin America, type II is rare and atypical strains predominate. Experts assessed the T. gondii genotypes in humans in North America. Unlike Europe, T. gondii atypical genotypes are common in humans in North America and unlike Latin America, type II strains are still present with significant frequency. An awareness that atypical genotypes are common in North America and have been associated with severe ocular and systemic disease and unusual presentations of toxoplasmosis in immunocompetent patients, should be created among the clinicians.