Ryu ES, Chang SJ, An J, et al. - Researchers sought to illustrate the predictive risk factors of lymph node metastasis (LNM) in patients with early gastric cancer (EGC) in relation to gender-specific differences. They analyzed data of 1076 patients [mean age 59.6 years; 69% men] with EGC who underwent surgical treatment at Gachon University Gil Medical Center, South Korea, from January 2003 and February 2016. Of 1076 patients (mean age 59.6 years), 69% were men. They observed an overall LNM rate of 9.4%. Relative to women, men exhibited lower LNM rate was lower in men (12.9% vs 7.8%). As per the multivariate analysis, independent predictive risk factors of LNM in EGC are elevated type, submucosal invasion, undifferentiated type, and lymphovascular invasion (LVI) among men. However, among women, only submucosal invasion and LVI were identified as independent predictive risk factors of LNM in EGC. In both men and women, LNM was observed in correlation with submucosal invasion and LVI. However, men but not women had elevated and undifferentiated types as risk factors. Researchers recommend clinicians to acknowledge these gender-specific differences with regard to individualized management.