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Gender differences in risk factors associated with pulmonary artery systolic pressure, heart failure, and mortality in blacks: Jackson Heart study

Journal of the American Heart Association Jan 10, 2020

Lakshmanan S, et al. - Given the prevalence of pulmonary hypertension in black individuals, particularly women and the association of elevated pulmonary artery systolic pressure (PASP) with significant morbidity and mortality, researchers developed linear and proportional hazards models to investigate potential gender-related differences in risk factors for elevated PASP (estimated by transthoracic echocardiography) and PASP-associated clinical outcomes (incident heart failure admissions and mortality) in JHS (Jackson Heart Study) participants. Participants with assessable transtricuspid gradients (n = 3,286) at the time of first/baseline examination, 2000–2004, comprised the study cohort. The analysis revealed association of specific cardiopulmonary risk factors with raised PASP in black women and men. In women, BMI and obstructive and restrictive spirometry patterns are connected with raised PASP and in men, chronic lung disease is associated with PASP rise. The risk of incident heart failure admissions was higher for women with elevated PASP, compared with men.
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