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Gender differences in patients receiving left ventricular assist devices for end- stage heart failure

JACC: Heart Failure Sep 03, 2020

Gruen J, Caraballo C, Miller PE, et al. - To ascertain gender disparities in the use and clinical results of left ventricular assist devices (LVAD), researchers used INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) findings. From the INTERMACS study, patients who had implantation of their first continuous-flow LVAD between 2008 and 2017 were enrolled. Experts performed survival analyses stratified by gender. This study involved 18,868 patients, with 3,984 (21.1%) women. Findings revealed the presence of a higher risk of death and adverse events following LVAD in women. Experts noted that only 1 in 5 LVADs were implanted in women, and the likelihood of undergoing a heart transplant was less in women compared with men. There is a requirement for further inquiry to understand reasons of adverse events and potential underuse of advanced treatment choices in women.

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