Lau ES, Cunningham T, Hardin, KM, et al. - Researchers examined if men and women with heart failure with preserved ejection fraction (HFpEF) differ in terms of cardiometabolic profiles and exercise hemodynamic parameters. In this cross-sectional study including 295 participants, 121 (41.0%) were men (mean [SD] age, 64 [12] years) and 174 (59.0%) were women (mean [SD] age, 61 [13] years). Men and women with HFpEF showed similar reductions in the percent predicted peak maximum level of oxygen consumption. However, women vs men had greater deficits in oxygen delivery and utilization during exercise despite a lower burden of comorbidities in a cohort of rigorously defined HFpEF. Findings thereby highlight that the cardiac and skeletal muscle responses to exercise in HFpEF differ by gender.