Hara H, Takahashi K, van Klaveren D, et al. - Given that the optimal revascularization beyond 5 years by gender has not been assessed in the SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) trial which demonstrated a significant difference in the impact of treatment with percutaneous coronary intervention (PCI) vs coronary artery bypass grafting surgery (CABG) on death at 5 years between women and men, so, researchers explored the influence of gender on death and sex-treatment interaction at 10 years. Participants were 1,800 patients with de novo 3-vessel and/or left main coronary artery disease who were randomized to treatment with PCI or CABG in the SYNTAX trial. A higher 10-year death rate was observed in women vs men (32.8% vs 24.7%). Overall, in patients suffering from complex coronary artery disease, female gender was not an independent predictor of death at 10 years. At 10 years, there was no more an interaction between gender and treatment with PCI or CABG that was noted at 5 years.