Hong SH, Lee JS, Kim JA, et al. - In a Korean population without previous heart failure (HF), ischaemic heart disease or liver disease, researchers determined if there existed a link between gamma-glutamyl transferase (GGT) variability and the incidence of hospitalisation for heart failure (HHF) in this longitudinal cohort investigation. From the Korean National Health Insurance Service-National Health Screening Cohort, a total of 119,201 individuals were examined. They computed GGT variability as the coefficient of variation (CV), SD and variability independent of the mean. A follow-up of 8.4 years was performed. The HR of HHF was estimated to be 1.22 in the highest quartile of GGT variability vs the lowest quartile, as evaluated by CV following adjustment for confounding factors, including alcohol intake as well as mean GGT levels, in the multivariable-adjusted model. In this study, variability in GGT was shown to be independently related to the incidence of HHF. The likely usefulness of higher GGT variability was suggested as an indicator of future risk of HF.