Chaemsaithong P, Sahota D, Pooh RK, et al. - Researchers examined whether the European-derived biomarker multiple of median (MoM) formulae could be applied for the risk assessment of preterm preeclampsia (PE) across seven Asian populations spanning the East, Southeast and South Asian regions of the continent. In addition, they performed a quality assurance (QA) assessment of the biomarker measurements; and sought to establish criteria for prospective ongoing measurement QA assessment. In 11 recruiting centers in China, Hong Kong, India, Japan, Singapore, Taiwan and Thailand, they performed a non-intervention, multicenter study in 4,023 singleton pregnancies at 11-13⁺⁶ weeks for this purpose. The total screened population had the median (95% confidence interval (CI)) MoM values of mean arterial blood pressure, uterine artery pulsatility Index, and placental growth factor of 0.961 (0.958-0.965), 1.018 (0.996-1.030) and 0.891 (0.861-0.909), respectively. The analysis revealed anthropometric differences in Asian women, owing to this, there were significant changes in the biomarkers for PE screening, especially mean arterial blood pressure and placental growth factor, requiring Asian-specific formulae for the calculation of MoMs to be developed if reliable and consistent patient-specific risks for preterm PE are to be reported. In this work, the importance and need for regular quality assessment of biomarker values are highlighted.