Rahimzadeh M, et al. - Researchers conducted the first study investigating the efficacy of novel antibiotics, namely ceftazidime-avibactam (CZA) and ceftolozane-tazobactam (C/T), against P. aeruginosa isolates from patients with UTI in Iran. Further, they assayed the genetic diversity of the resistant isolates. From patients with UTI in Tehran, Iran, they collected a total of 200 P. aeruginosa isolates; of these, 16 (8%) were identified as resistant to CZA and C/T using Disk diffusion and Minimum Inhibitory Concentration (MIC) methods. They identified a high resistance of the resistant isolates towards the other classes of antibiotics. Using the combination disk diffusion test (CDDT), they identified 31.2% and 75% of the resistant isolates as extended-spectrum β-lactamases and Metallo Beta Lactamase producers, respectively. bla_OXA10, bla_VIM, bla_OXA48, bla_OXA2, and bla_CTX-M were prevalent in 100%, 50%, 31.2%, 25%, and 12.5%, respectively. Furthermore, bla_PER and bla_NDM genes were identified two isolates (12.5%). Grouping of the resistant isolates into 14 distinct pulsotypes was done and recognition of two shared pulsotypes was made. Observations revealed a high activity of CZA and C/T against the P. aeruginosa isolates. They recommend considering the low rate of resistance to the antibiotics to avoid further spreading of the antibiotic resistance among the P. aeruginosa and the other bacteria.