LaRocca G, et al. – Researchers presumed tissue inhibitor metalloproteinase–1 and matrix metalloproteinase–9 (TIMP–1 and MMP–9) as predictors of all–cause mortality and they evaluated the incremental value of these biomarkers when adjusting for clinical and other biomarkers. They reported that TIMP–1 most strongly predicted all–cause mortality after age. Findings also underscored the possible pathological relevance as well as prognostic significance of the metabolic pathways regulating extracellular matrix homeostasis and fibrogenic processes.