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Fibrosis and wall thickness affect ventricular repolarization dynamics in hypertrophic cardiomyopathy

Annals of Noninvasive Electrocardiology Jul 15, 2018

Jalanko M, et al. - In this study involving hypertrophic cardiomyopathy (HCM) patients with either the MYBPC3-Q1061X or TPM1-D175N mutation and control subjects without mutation and hypertrophy, researchers studied the link between the phenotype and ventricular repolarization dynamics in HCM. They found that hypertrophy and fibrosis had an impact on the dynamics of ventricular repolarization in HCM. They also noted that the arrhythmogenic potential in HCM may be increased due to a possible independent impact of late gadolinium enhancement on QT dynamics.

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