Miketinas DC, et al. - Researchers used data from the POUNDS Lost (Preventing Overweight Using Novel Dietary Strategies) Study (a randomized trial that assessed the impacts of calorie-restricted diets varying in macronutrient composition on weight loss in adults) to evaluate dietary fiber as a predictor of weight loss in participants who consumed calorie-restricted diets (−750 kcal/d from estimated energy needs) for 6 mo. Randomly, they divided data to a training data set (70%). Using adjusted Least Absolute Shrinkage and Selection Operator and model averaging, they identified the impacts of fiber and other weight-loss predictors in the training data set (70%). To evaluate predictive performance, they then fit retained predictors on the testing data set. In this study with 345 participants (53.9% female) [mean ± SD age and BMI being 52.5 ± 8.7 y and 32.6 ± 3.9 kg/m², respectively, for the entire sample], weight loss and dietary adherence were promoted by the consumption of dietary fiber, independently of macronutrient and caloric intake, in adults with overweight or obesity consuming a calorie-restricted diet.