Li W, Shu S, Cheng L, et al. - Researchers intended to determine if there is a potential association between fasting serum total bile acids (TBA) and the presence of CAD, myocardial infarction (MI) and severity of coronary lesions. In total, 7,438 consecutive patients with suspected CAD, who had undergone coronary angiography, were recruited. Using the Gensini score (GS), the severity of coronary lesions was assessed. According to findings, CAD patients had lower serum TBA compared with non-CAD individuals, and patients with MI had lower TBA compared with non-CAD patients. Findings suggested an independent and significant association of lower TBA concentration (less than the median 3.6 μmol/L) with the presence and severity of CAD, particularly for the presence of MI. In patients undergoing coronary angiography for suspected CAD, the fasting serum TBA level was highly related to the presence and severity of CAD.