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Familiality of psychiatric disorders and risk of postpartum psychiatric episodes: A population-based cohort study

American Journal of Psychiatry Aug 12, 2018

Bauer AE, et al. - Researchers linked Danish birth and psychiatric treatment registers to investigate how family history of psychiatric disorders is associated with postpartum psychiatric disorders in proband mothers with and without a prior psychiatric history by assessing degree of relationship, type of disorder, and sex of family members. They analyzed probands who were first-time mothers, born in Denmark in 1970 or later and gave birth after age 15 and before Dec. 31, 2012 (N=362,462). Postpartum psychiatric disorders were significantly associated with family history of psychiatric disorders, especially bipolar disorder. Women at risk for postpartum psychiatric disorders could be identified via questions related to female and male first-degree relatives with bipolar disorder. These questions appear to be of the highest importance and thus are recommended to be added to routine clinical screening guidelines to improve prediction of risk.
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