Kops NL, et al. - Via a cross-sectional, nationwide, multicenter study on 6,388 sexually active young adults from 119 primary healthcare centers between September 2016 and November 2017, researchers investigated factors related to genital human papillomavirus (HPV) and other self-reported sexually transmitted infection (STI) co-infections, one of the most common global health problems, among women and men aged 16–25 years from Brazil. There were 276 with HPV/STI co-infection out of 3,512 people who had valid data for genital HPV and STI-positive status. HPV/STI co-infection was more common in men vs HPV infection alone. In comparison to HPV infection alone, risk factors that were uniquely correlated to HPV/STI coinfection were smoking, drug use and ever having a same-sex sexual experience. A low prevalence of self-reported STIs was observed, however, the prevalence of HPV was high in participants with at least one STI. These results reinforce the importance among Brazilian young adults of strategies to prevent risky behaviors.