Rao SG, et al. - Researchers examined HIV-infected adults vs HIV-uninfected controls for the pooled relative risk (RR) of incident acute myocardial infarction (AMI). In addition, they investigated how traditional and HIV-related risk factors contribute to this. Sixteen studies (N = 1,619,690, median age 38.5 years, 78.9% male, mean follow-up of 6.5 years) were identified reporting AMI incidence rates among HIV-infected or HIV-infected and matched uninfected adults. Outcomes revealed a 2-fold higher AMI risk in correlation to chronic HIV infection. Among HIV-infected adults, traditional risk factors hypertension, dyslipidemia, and smoking were noted as contributing to AMI risk significantly; they recommend aggressively targeting these factors in routine HIV care.