Li X, Lin Y, Wang S, et al. - Researchers examined the link of serum extracellular superoxide dismutase (Ec‐SOD) activity with left ventricular (LV) geometry, as well as heart failure (HF) among patients with cardiovascular disease (n = 1,047) in this cross‐sectional analysis. They found, in multinomial logistic regression analysis, that each 10 U/mL rise in serum Ec‐SOD activity was related to a 16.5% reduction in the odds of concentric remodeling without HF, a 40.4% decline in the odds of concentric hypertrophy with HF, a 16.1% reduction in the odds of eccentric hypertrophy without HF and a 34.0% decline in the odds of eccentric hypertrophy with HF. Overall, findings demonstrated independent link of serum Ec‐SOD activity with abnormal LV geometry patterns with and without overt HF. In patients with cardiovascular disease, a potential connection between LV structure remodeling and the occurrence of subsequent HF might be Ec‐SOD.