Krzyzanowska A, et al. - To analyze the correlation between expression and disease outcome, the expression of total STAT3 (tSTAT3) and two forms of activated phosphorylated STAT3 (pSTAT3⁷²⁷, and pSTAT3⁷⁰⁵) were assessed in tissue microarrays (TMA) of two cohorts of localized hormone-naive prostate cancer (PCa). Although, they noticed no improvement in the prognostic value of Gleason score or pathological T stage with pSTAT3 and tSTAT3 expression, they found a relationship between low pSTAT3⁷²⁷and pSTAT3⁷⁰⁵ expression in epithelial cells of cancerous prostatic glands in hormone-naive PCa and quicker progression of disease.