Logie CH, Wang Y, Lalor P, et al. - As HIV transmission dynamics are influenced by sex workers’ work environment, researchers here applied the Structural HIV Determinants Framework to ascertain the correlations between the work environment of public spaces and HIV infection risks among sex workers in Jamaica, considering macro-structural (police harassment) and intrapersonal (depression) pathways. A cross-sectional survey was implemented with sex workers in Kingston, Ocho Rios, Montego Bay, and nearby towns in Jamaica. As per data gained, there was a significant indirect effect of public place of sex work on self-reported HIV-positive serostatus; depression and police harassment mediated this relationship. Findings suggest that in contexts of criminalization, the sex work environment can increase the exposure to police violence and depression, in turn raising HIV vulnerabilities.