Ness KK, Plana JC, Joshi VM, et al. - In this study performed with 1,041 individuals who had survived cancer ≥ 10 years (and had or did not have exposure to anthracyclines and/or chest-directed radiation) and 285 controls, researchers focused on the prevalence of exercise intolerance in survivors exposed or not to cardiotoxic therapy, as well as looked at the links among organ system function, exercise intolerance, and mortality. Factors that were found to be related to exercise intolerance were: global longitudinal strain, chronotropic incompetence; forced expiratory volume in 1 second < 80%, and 1 SD reduction in quadriceps strength. There was no link between ejection fraction < 53% and exercise intolerance. Among childhood cancer survivors, they found that exercise intolerance was prevalent. The link of exercise intolerance with all-cause mortality was also identified. An increased risk was observed in relation to treatment-related cardiac (detected by global longitudinal strain), autonomic, pulmonary, and muscular impairments. There may be a need to refer survivors with impairments to trained specialists to learn to accommodate specific deficits when engaging in exercise.