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Excess mortality and undertreatment of women with severe aortic stenosis

Journal of the American Heart Association Jan 07, 2021

Tribouilloy C, Bohbot Y, Rusinaru D, et al. - Researchers sought to determine the impact of gender on the presentation, treatment, and outcome of patients suffering from aortic stenosis (AS). They assessed 5‐year excess mortality and performance of aortic valve replacement (AVR) stratified by gender in a cohort comprising a total of 2,429 patients experiencing severe AS (49.5% women). Smaller aortic valve area but similar mean transaortic pressure gradient were detected in women when compared with men. Findings revealed that being diagnosed at later ages and presence of more symptoms were observed in women with severe AS vs men. Less often AVR was received by women despite prevalent symptoms and also 5‐year excess mortality was evident in women compared with men, even following age matching. There is a need to address these disparities so that both genders may receive equivalent care for severe AS.

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