Abdel-Qadir H, Singh SM, Pang A, et al. - Researchers conducted a population-based cohort study with the aim to determine the risk of stroke without anticoagulation therapy in individuals with AF aged 66 to 74 years without other CHA₂DS₂-VASc (congestive heart failure, hypertension, age ≥ 75 years, diabetes, stroke, vascular disease, age 65-74 years, female gender) risk factors. In addition, they investigated the correlation of stroke incidence with patient age. A total of 16,351 individuals with AF (median [interquartile range] age, 70 [68-72] years) were included; of these individuals, 6,314 (38.6%) initiated anticoagulation therapy during follow-up. The overall 1-year risk of stroke was 1.1% without anticoagulation; the risk did not differ significantly by gender. As age increased, the risk of 1-year stroke more than doubled, from 0.7% at 66 years to 1.7% at 74 years. Overall findings suggest that anticoagulation therapy is more frequently beneficial in older rather than younger AF patients without non–gender-related CHA₂DS₂-VASc risk factors.