Antiochos P, Ge Y, Steel K, et al. - In this retrospective, multicenter cohort study, researchers investigated the utility of stress cardiac magnetic resonance (CMR) imaging for risk reclassification in patients without a history of coronary artery disease (CAD) who presented with suspected myocardial ischemia. The sample consisted of 1,698 consecutive patients (median follow-up, 5.4 years) aged 35 to 85 years with 2 or more coronary risk factors but no history of CAD who presented with suspected myocardial ischemia to undergo stress CMR imaging. In this multicenter cohort of individuals without a history of CAD with suspected myocardial ischemia, stress CMR imaging reclassified patient risk across guideline-based risk categories, beyond clinical risk factors. This study findings support the importance of stress CMR imaging for clinical decision making, particularly in patients at intermediate risk of CV death and nonfatal myocardial infarction.