Porcino GN, et al. - Among residents of Teresina, Piauí state, Brazil, an endemic region for Visceral Leishmaniasis, researchers assessed the diagnostic performance of various tests to detect asymptomatic individuals. Among patients presenting with active Visceral Leishmaniasis, 76% and 64% were detected employing Kalazar Detect and OnSite, respectively, positivity in these tests was still evident post-treatment in 50% and 57% of patients, respectively. With both of the immunochromatographic tests, only 1.7% of healthy participants residing in the endemic area were found positive. Blood samples from 37.9% of infected people dwelling in the endemic area exhibited the presence of L. infantum DNA, while 26.7% of them had IFN-γ-induced protein 10 and monokine induced by IFN-γ biomarkers present. The occurrence of greatest concordance of positivity between ELISA and real time PCR was reported. Overall, asymptomatic infections can be detected via the association of various methods.