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Evaluating the 1-h postload glucose level to predict future type 2 diabetes

Diabetes Research and Clinical Practice Feb 24, 2020

Saunajoki AE, et al. - Researchers investigated the predictive value of 2-h postload glucose level as well as fasting and 1-h glucose levels in predicting the risk of type 2 diabetes. From a prospective population-based cohort study, they assessed 654 individuals without type 2 diabetes at baseline who underwent oral glucose tolerance test (OGTT), with measurement of glucose at 0, 60, and 120 min at baseline, and after 12 years in a follow-up survey. The predictive properties of fasting, 1- and 2-h postload glucose levels were assessed via comparing the areas under the receiver-operating characteristic (ROC) curve. No significant increase in the predictability of type 2 diabetes was attained with adding 2-h glucose concentration in the prediction model with fasting and 1-h glucose levels vs a model only including fasting and 1-h glucose levels. The largest area under the ROC curve was generated for 1-h glucose level (AUC 0.81), vs fasting (AUC 0.71) and 2-h glucose levels (AUC 0.72).
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