Nduba V, et al. - As pulmonary tuberculosis is not reliably prevented with Bacillus Calmette-Guerin (BCG), the tuberculosis (TB) vaccine given at birth, adolescents seems to be prime candidates to receive new more effective TB vaccines, so researchers investigated the annual risk of infection with Mycobacterium tuberculosis (MTB) among 12-18-year olds. As part of a study on TB prevalence and incidence, they performed a tuberculin skin test (TST) survey. A TST was considered positive if it was of ≥ 10 mm if HIV negative or ≥ 5 mm if HIV positive. Among 4,808 adolescents returning for TST readings, latent TB infection was prevalent in 1,544 with a corresponding annual risk of 2.6%. of TB infection. This study thereby indicated high TB transmission rates, implying that adolescents in schools in this region may be a suitable target group for TB vaccine trials including TB vaccine trials intending to prevent infection. Being male, history of having a household TB contact, having a BCG scar, living in a rural area, and being out of school were identified as risk factors for a positive TST.