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Epstein–Barr virus (EBV) incidental expression in bone marrow cells, a study of 230 consecutive bone marrow biopsy samples

Human Pathology Apr 05, 2019

Farrell D, et al. - In this retrospective analysis, researchers assessed the rate of detection of Epstein–Barr virus (EBV) expression in 230 consecutive bone marrow samples. In cases with available follow-up data, they tried to correlate any positive findings with different clinical parameters including patient's age, sex, clinical history, immune status, and any neoplastic transformation. By in situ hybridization, they found 5 cases (2.17%) with scattered EBV-positive cells. The largely small size of observed scattered EBV-positive cells was evident, and these cells likely represented bystander, latently infected cells. In immunodeficient individuals vs in immunocompetent patients, a slightly higher rate of detection of EBV-positive cells in the bone marrow was observed; 3% and 1%, respectively.
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