Joffre J, et al. - In a population of critically ill patients admitted to intensive care unit (ICU) for infective endocarditis (N=4,405), researchers examined demographical, comorbidities, organ failure, and pathogen-related features as well as focused on risk factors of in-ICU mortality in this retrospective observational multicenter (N = 34) study of the CUB-Rea (Collège des Utilisateurs des Bases des données en Réanimation) register. The endocarditis prevalence, as well as organ failure severity over the three periods (1997–2003, 2004–2009, and 2010–2014) was found to be increased. More frequent use of valve surgery was reported while a significant reduction in in-ICU mortality was observed. Factors related to ICU mortality in multivariate analysis were age, Simplified Acute Physiology Score 2, organ failure, stroke, and Staphylococcus sp. Conversely, a better outcome was observed in relation to surgery, intracardiac devices, male gender, and Streptococcus sp.-related infective endocarditis. Substantial changes in microbial epidemiology were also evident.