Akello JO, Kamgang R, Barbani MT, et al. - Researchers investigated long-term epidemiological trends and genotypic relatedness among circulating human adenovirus (HAdV) strains via analyzing samples from hospitalized patients confirmed to be HAdV positive in Bern, Switzerland, from 1998 to 2017. They identified HAdV in 1,302 samples tested. The findings yield novel insights on long-term epidemiological trends and phylogenetic relatedness among circulating HAdV strains in Switzerland, country. No clear seasonality for cases of HAdV infection was observed. The highest positivity rate was observed in upper respiratory tract samples, conjunctivitis swabs, and stool (56.2%, 18.7%, and 14.2% of the cases, respectively). Children ≤ 4 years old had highest HAdV infection. Years 2009 (n = 110) and 2010 (n =112) had increased number of HAdV cases. Patients older than 20 years had HAdV8 as the predominant genotype, which was mostly linked with ophthalmic infection. Children ≤ 4 years old had HAdV1, HAdV2, and HAdV3 as the predominant genotypes, which were mostly associated with respiratory tract infections. Among children ≤ 4 years old, they identified recurring peaks of increased HAdV cases every 4 years.