Bancks MP, et al. - In this investigation involving 4,300 adults with diabetes, researchers described unique diabetes phenotypes among National Health and Nutrition Examination Survey (NHANES) candidates and evaluated correlations with race/ethnicity, CVD risk factors, and prevalent complications. Candidates (age ≥ 20 years) were included from NHANES exams 2003-04 through 2013-14 with diabetes (self-report of diabetes diagnosis or medication use, fasting glucose ≥ 7.0mmol/L, random glucose ≥ 11.1mmol/L, and glycated hemoglobin (HbA1c) ≥ 48mmol/mol). Four unique subgroups of diabetes were identified related to aging, severe obesity, severe hyperglycemia, and young adulthood-onset. Differences were observed in subgroup proportion by race/ethnicity. All groups had higher HbA1c and BMI compared to the AR phenotype, the young adulthood-onset (YA) and severe obesity groups had higher blood pressure, and the YA group had a higher prevalence of complications of renal, eye, and neuropathy. It is worth evaluating whether considering diabetes phenotypes with treatment strategies reduces the incidence of diabetes, morbidity, and mortality.