van Woerden G, et al. - Given the possible role adipose tissue and inflammation may play in the pathophysiology of patients with heart failure (HF) with mildly reduced or preserved ejection fraction, researchers assessed epicardial fat in patients with HF with preserved (HFpEF) and mid-range ejection fraction (HFmrEF), and its association with co-morbidities, plasma biomarkers and cardiac structure. Participants were 64 HF patients with left ventricular ejection fraction > 40% and 20 controls. HF patients and controls were of comparable age, sex and body mass index. They detected more epicardial fat in HF patients vs controls, despite comparable body mass index. They observed a link between epicardial fat volume and the presence of atrial fibrillation and type 2 diabetes mellitus and with biomarkers related to myocardial injury.