Cheung WH, Wong RMY, Choy VMH, et al. - Researchers conducted this study to assess the role of vibration treatment for the improvement of osteoporotic fracture healing. A recent in vivo study was performed to analyze the morphological and functional changes of osteocytes after vibration treatment in an osteoporotic metaphyseal fracture rat model. The data indicated that vibration treatment induced significant outgrowth of canaliculi and altered expression of various proteins (E11, dentin matrix protein 1 (DMP1), FGF23 and sclerostin), especially osteocyte-specific DMP1 which was greatly elevated. This study's findings demonstrate that in osteoporotic fracture bone, osteocyte is the major cell type to sense mechanical signals and help downstream healing. While randomized controlled trials are needed to confirm its efficacy, vibration treatment has good potential to be translated for clinical application to benefit osteoporotic fracture patients.