Fujiwara T, et al. - Endplate and intervertebral disc (IVD) injuries correlated with single- and acute-osteoporotic vertebral fractures (OVFs, VFs are the most prevalent skeletal injury occurring from osteoporosis within the growing population of old people) were retrospectively assessed using magnetic resonance imaging (MRI) by the researchers in order to assess the incidence and occurrence pattern of endplate and IVD injuries associated with single- and acute-OVFs and to assess the impact of endplate and IVD injuries on the occurrence of delayed union. Endplate injuries and IVDs lesions were noted in 103 of the 168 vertebrae and 101 of 168 OVFs and the occurrence of both injuries was significantly correlated, in association with OVFs. The multivariate analysis illustrated that intravertebral signal alternation (focal high signal intensity) and posterior wall injury were independent risk factors that prognosticated delayed union, however, no important relation to endplate and IVD injuries was recognized. Hence, endplate and IVD injuries were discovered in approximately 60% of single and acute OVFs. Moreover, among the three components of the anterior spinal column, fracture healing of OVFs would be mainly associated with vertebral factors, including mechanical stress and metabolic status.