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Endothelin 1 is associated with heart failure hospitalization and long-term mortality in patients with heart failure with preserved ejection fraction and pulmonary hypertension

Cardiology Sep 20, 2019

Chowdhury MA, Moukarbel GV, Gupta R, et al. - In this single center prospective cohort study, researchers focused on the role of big endothelin 1, endothelin 1 (ET1), and neprilysin in heart failure with preserved ejection fraction (HFpEF) with pulmonary hypertension (PH). Participants were 90 patients having HFpEF; 30 with no PH, 30 with postcapillary PH, and 30 with combined post- and precapillary PH. Increased ET1 in pulmonary veins (endothelin from the wedge; ET1W) was seen in patients with HFpEF-PH vs controls. The link of ET1W levels with both PH and pulmonary vascular resistance was identified. In HFpEF patients, 1-year heart failure hospitalization was predicted by ET1W and ET1 gradient (ET1G), while a link was evident between elevated ET1G levels and long-term mortality. ET1 was shown to have a role in PH development in HFpEF. The potential of ET1 as a prognostic biomarker was also explored.
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