Miramontes-González JB, et al. - Researchers sought to characterize the influence of VEGFR2 and OPG genes polymorphisms on the expression of atherosclerotic cardiovascular disease (ASCVD) in familial hypercholesterolemia (FH) patients. From the SAFEHEART registry, 318 FH patients without clinical diagnosis of ASCVD were studied. Via coronary tomographic angiography (CTA), they ascertained the presence of coronary stenosis and coronary artery calcium, as measured by coronary calcium score (CCS) and via using TaqMan 5′-exonuclease allelic discrimination assays, they performed genotyping of OPG rs2073618 and VEGFR2 rs2071559 polymorphisms. Outcomes revealed modification in the risk of ASCVD in FH patients in correlation with polymorphisms in VEGFR2 and OPG genes. They observed decreased risk of accumulation of coronary artery calcium measured by CCS in CTA in correlation with homozygous GG genotype and G allele of VEGFR2 rs2071559 polymorphism. Moreover, the risk of the presence of coronary artery calcium measured by CCS in CTA was higher among the carrier of the GG genotype and G allele of the OPG rs2073618 polymorphism.