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Histoplasma capsulatum and Pneumocystis jirovecii coinfection in hospitalized HIV and non-HIV patients from a tertiary care hospital in Mexico

International Journal of Infectious Diseases Sep 13, 2019

Carreto-Binaghi LE, Morales-Villarreal FR, García-de la Torre G, et al. - Researchers reported on the coinfection with Histoplasma capsulatum and Pneumocystis jirovecii. Specific molecular methods were used for detection of each fungus in the bronchoalveolar lavage (BAL) samples from 289 hospitalized patients from a tertiary care hospital. The patients were separated into three groups in accordance with PCR findings: the first group consisted of 60 (20.8%) histoplasmosis patients; the second, 45 (15.6%) patients with pneumocystosis; and the last group, 12 (4.2%) patients with coinfection. BLASTn and neighbor-joining algorithms indicated high similarity among the generated sequences of each species. HIV-positive patients displayed higher estimated prevalence of coinfection with H. capsulatum and P. jirovecii .

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