Elevated thrombospondin-2 contributes to delayed wound healing in diabetes
Diabetes Aug 13, 2019
Kunkemoeller B, Bancroft T, Xing H, et al. – In this study, researchers determined if the expression of thrombospondin-2 (TSP2) is correlated with delayed healing in diabetes. They discovered that TSP2 expression was raised in diabetic mice as well as the skin from diabetic patients. They developed a novel diabetic TSP2-deficient model to determine the contribution of TSP2 to impaired healing in diabetes. In order to increase the expression of TSP2, high glucose mechanistically increased activation of the hexosamine pathway and NF-κB signaling. According to findings, the expression of TSP2 induced by hyperglycemia may contribute to impaired diabetes healing.
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